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Excellent Science for New Therapies

Chronic inflammmation, triggered by dysfunctions on the boundary surfaces of the body’s organs and their interaction with the environment, represents a central challenge for modern medicine. It is considered to be the cause of many chronic diseases, which have been steadily increasing in recent decades – especially in western industrialized countries.

The goal of the Cluster of Excellence in Inflammation Research is to decode the molecular basis of chronic inflammatory diseases, as well as the complete identification of metabolic and signaling pathways as an approach to therapies and prevention.

The unforeseen complexity and the breadth of possible triggers of inflammatory diseases require new scientific structures and practices. In the Excellence Cluster, key elements of the origins of inflammation will be examined in detail on genetic, genomic and functional levels.

The cluster is a joint venture of Kiel University and the University of Lübeck, together with the Schleswig-Holstein University Medical Center, the Leibniz Research Center Borstel, the Max Planck Institute for Evolutionary Biology, Plön, and the Muthesius Academy of Fine Arts and Design in Kiel.

Researching and Treating Inflammation

Das DFG-Videoportal zur Exzellenzinitiative

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Newsroom
DNA regions yield new clues
Apr 21, 2013
Members of the Cluster of Excellence Inflammation at Interfaces and their international partners have performed the world’s largest genetic study of primary sclerosing cholangitis and have succeeded in identifying nine new risk regions for this chronic inflammatory disease of the bile ducts. The findings of this study have now been published in Nature Genetics.
Cluster of Excellence to Meet in Hamburg
Feb 07, 2013
Explaining the genetic and molecular causes of chronic inflammatory diseases such as Crohn's disease, rheumatoid arthritis or allergies is one of the greatest challenges faced by modern medicine. On February 22 and 23, experts from the field of inflammation research will meet at the 4th Interdisciplinary Symposium ‘Inflammation at Interfaces’ held by the Cluster of Excellence Inflammation at Interfaces at the Congress Center in Hamburg (CCH).
A precise fit for protein sorting: molecular basis of recognition
Dec 11, 2012
Up to now it was unknown how cargo proteins get sorted into COP I coated vesicles that mediate their transport to several intracellular destinations inside cells. Recently, scientists of the Cluster of Excellence Inflammation at Interfaces in collaboration with researchers of the University of Cambridge (UK) found out how newly made proteins get efficiently sorted into these transport vesicles. The results from this study were published on 11th December 2012 in the print version of Developmental Cell.
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