RESEARCH AREA A
Genetic Etiology Research
SNP-Genotyping and association studies in large patient samples have revealed disease genes in Crohn disease, ulcerative colitis, coronary heart disease, atopic eczema, psoriasis, sarcoidosis, longevity and periodontitis. Second generation sequencing technologies are currently used to analyze the metagenome and metatranscriptome of microbial flora on barriers in human beings and to study the evolution of complex microbial communities in animal models.
Hydra, a valuable invertebrate model for fast generation of transgenic organisms, will be of particular importance in understanding human barrier disorders by providing insight in both the ancient mechanisms of host/microbial interactions and the resulting evolutionary selection processes.
Spotlight on facilities: 800.000 SNPlex/40.000 TaqMan genotypes per day. Second generation sequencing core with Roche Gs-FLX and 3 ABI Solid. CE-applications on four ABI 3730. Automated (robotic) sample handling. LIMS for data collection. Bioinformatics support group.
Participating institutions: Universities Kiel (Biology, Medicine) and Lübeck (Medicine), MPI Evolutionary Biology, Plön
Spotlight on people: several young professors (50% female) through cluster funding
Coordinators:
Stefan Schreiber (Gastroenterology, Molecular Biology), University Kiel
Phone: +49 431 5972350, E-Mail: Stefan Schreiber
Thomas Bosch (Developmental Biology, Zoology), University Kiel
Phone: +49 431 8804169, E-Mail: Thomas Bosch
Junior Research Group I-a: Genetics of Granulomatous Diseases
The ultimate goal of this research area is to elucidate the genetic basis of granulomatous inflammatory diseases (sarcoidosis, tuberculosis, berylliosis).
Coordinator:
Sylvia Hofmann, University Kiel
Phone: +49 431 5971306, E-Mail: Sylvia Hofmann
