RESEARCH AREA C
Cellular and Molecular Principles
It is to address mechanisms of cellular interactions and regulatory molecules in acute and chronic inflammatory responses. This will be studied by generating relevant transgenic mouse models, cell culture systems, innovative biochemical separation and functional read-out technologies. Planned is the study of receptor trafficking mechanisms, e.g. their surface expression, subcellular localization, internalization pathways in different immune cells (mast cells, macrophages, T cells).
The gp130 family, IL-15R and the IL-10R family serve as examples of regulators of inflammation. Furthermore the evolutionary significance of the molecular pathways will be investigated and additional focus of interest is the characterization of antimicrobial peptides and proinflammatory fungal lipids.
Spotlight on facilities: confocal laserscan microscopy (Zeiss LSM510), FACSAria, multiphoton microscope (Lavision TriMScope), systematic analytical technologies for the molecular interactions on the subcellular level, state-of-the-art mass spectrometry and lipid chemistry, 2-D differential gel electrophoresis (DIGE) proteome analysis
Participating institutions: Universities of Kiel (Biology, Medicine) and of Lübeck (Medicine) and Research Center Borstel
Spotlight on people: Junior Research Groups and independent investigators.
Coordinators:
Silvia Bulfone-Paus (Immunology and Cell Biology), Research Center Borstel
Phone: +49 4537 188200, E-Mail: Silvia Bulfone-Paus
Dieter Kabelitz (Immunology, University Kiel)
Phone: +49 431 5973340, E-Mail: Dieter Kabelitz
Junior Research Group I-c: Molecular Prevention/Molecular Nutrition
Systematic approach to investigate how nutrition affects inflammation in response to genotype
Coordinator:
Gerald Rimbach, University Kiel
Phone: +49 431 8802583, E-Mail: Gerald Rimbach
